ALLODD
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ALLOstery in Drug Discovery

The ALLODD project is a collaboration between 13 academic and industrial organizations with 14 ESR/PhD positions available. The aim of ALLODD is to train a new generation of scientists to exploit the concept of allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems.

Why allostery in drug discovery?

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Most current drugs are designed to bind directly to the primary active sites (also known as orthosteric sites) of their biological targets. Allosteric modulators offer a powerful yet underexploited therapeutic approach. They can elicit a richer variety of biological responses and, since they target less conserved binding sites, higher selectivity and less adverse effects may be obtained (Changeux, Drug Disc Today 2013).

Our aim

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The ALLODD project aims to train a new generation of scientists in exploiting the concept of allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems.

Our approach

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Our approach is based on a combination of experimental and simulation techniques, including fragment Screening with structural characterization (X-ray, NMR, H/D exchange), proteomics (MS/MS), ITC, DNA encoding libraries, Virtual Screening, Molecular Dynamics simulations-based methods, Synthetic Chemistry, and in vitro and cellular assays for the verification of results.

Eyes on the Future

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Allosteric targeting need not be achieved solely through the design of synthetic small molecules, but also can also be reached via conformationally specific allosteric antibodies, which represents an important field of future research. There are already clear examples of monoclonal antibodies that allosterically target ion channels (Lee et al., 2014b), GPCRs (Mukund et al., 2013), and RTKs (De Smet et al., 2014), as well as cytokine and integrin receptors (Rizk et al., 2015; Schwarz et al., 2006).
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Project Coordinator
Dr. Zoe Cournia
BRFAA, Greece
Duration
01.09.2021-31.08.2025
Budget
€ 3 669 353,64
Funded under
  • H2020-EU.1.3.
  • H2020-EU.1.3.1.
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Grant agreement ID: 956314
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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  • Home
    • ALLODD Overview
    • Governing Bodies
  • People
    • Beneficiaries
    • Partner Organisations
    • Supervisors
    • Early Stage Researchers
  • Research
    • Work Packages
    • Individual Research Projects
  • Training
    • Training Events >
      • 1st Workshop and PhD Induction Course
      • 1st Training School & Networking Meeting
      • Allostery in Drug Discovery Awareness Event and Symposium
      • 2nd Training School & Networking Meeting
      • IPR Training for Researchers & ESR Presentations on the Progress of their Research
      • 3rd Training School & Networking Meeting
      • European Conference in Allostery in Drug Discovery >
        • Abstract submission
        • Registration
      • Final Networking Meeting
    • Secondments
    • ALLODD Webinars
    • Courses & Lectures
    • Journal Club
  • Dissemination
    • Publications
    • Dissemination Events
    • Science Slams
    • Communication Material
    • Social Media
    • Newsletter
  • Events
    • ALLODD Events
    • Satellite Events
  • Newsroom
    • Press releases
  • Job Openings
  • Blog
  • Contact