Early Stage Researchers
14 Early Stage Researchers will be recruited to the ALLODD network to be trained in allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems.
ESR1
"Development of a computational methodology to detect allosteric pathways in proteins and application in drug discovery"
Host Organization: Biomedical Research Foundation, Academy of Athens (BRFAA), Greece
Scientist-in-Charge: Dr. Zoe Cournia
Host Organization: Biomedical Research Foundation, Academy of Athens (BRFAA), Greece
Scientist-in-Charge: Dr. Zoe Cournia
ESR2
"Biophysical characterization of allosteric interactions using NMR spectroscopy"
Host Organization: University of Vienna (UNIVIE), Austria
Scientist-in-Charge: Dr. Christoph Rademacher
Host Organization: University of Vienna (UNIVIE), Austria
Scientist-in-Charge: Dr. Christoph Rademacher
ESR3
"Allosteric modulators of Fbw7 E3 ligase"
Host Organization: University of Barcelona (UB), Spain
Scientist-in-Charge: Prof. Xavier Barril
Host Organization: University of Barcelona (UB), Spain
Scientist-in-Charge: Prof. Xavier Barril
ESR4
"Excitation energy transfer applied to drug design"
Host Organization: University of Barcelona (UB), Spain
Scientist-in-Charge: Prof. Carles Curutchet
Host Organization: University of Barcelona (UB), Spain
Scientist-in-Charge: Prof. Carles Curutchet
ESR5
"Allosteric drugs development for receptor mosaics"
Host Organization: Forschungszentrum Julich GMBH (FZJ), Germany
Scientist-in-Charge: Prof. Giulia Rossetti
Host Organization: Forschungszentrum Julich GMBH (FZJ), Germany
Scientist-in-Charge: Prof. Giulia Rossetti
ESR6
"Structural elucidation of allosteric mechanisms in G-protein coupled receptors or other membrane proteins by structural biology methods"
Host Organization: Charite – Universitaetsmedizin Berlin (Charité), Germany
Scientist-in-Charge: Dr. Patrick Scheerer
Host Organization: Charite – Universitaetsmedizin Berlin (Charité), Germany
Scientist-in-Charge: Dr. Patrick Scheerer
ESR7
"Design and synthesis of covalent allosteric probes"
Host Organization: Research Center for Natural Sciences (RCNS), Hungary
Scientist-in-Charge: Dr. György Keserű
Host Organization: Research Center for Natural Sciences (RCNS), Hungary
Scientist-in-Charge: Dr. György Keserű
ESR8
"Design and synthesis of allosteric phosphatase inhibitors"
Host Organization: Lebninz-Research Institute for Molecular Pharmacology (FMP) in FORSCHUNGSVERBUND BERLIN EV (FVB), Germany
Scientist-in-Charge: Dr. Marc Nazaré
Host Organization: Lebninz-Research Institute for Molecular Pharmacology (FMP) in FORSCHUNGSVERBUND BERLIN EV (FVB), Germany
Scientist-in-Charge: Dr. Marc Nazaré
ESR9
"Identification of target binding sites using HDX MS and off-targets using Proteome Thermo Profiling"
Host Organization: Karoliska Institute, Sweeden
Scientist-in-Charge: Dr. Roman Zubarev
Host Organization: Karoliska Institute, Sweeden
Scientist-in-Charge: Dr. Roman Zubarev
ESR10
"Computer-aided drug discovery of GPCR allosteric modulators"
Host Organization: Heptares Therapeutics Limited (Heptares), United Kingdom
Scientist-in-Charge: Dr. Chris de Graaf
Host Organization: Heptares Therapeutics Limited (Heptares), United Kingdom
Scientist-in-Charge: Dr. Chris de Graaf
ESR11
"Rational design of positive and negative allosteric modulators of pLGICs"
Host Organization: University of Strasbourg (Unistra), France
Scientist-in-Charge: Prof. Marco Cecchini
Host Organization: University of Strasbourg (Unistra), France
Scientist-in-Charge: Prof. Marco Cecchini
ESR12
"Identification of new targets from screening using biochemical and cell based assays"
Host Organization: Merck Healthcare KGAA (Merck), Germany
Scientist-in-Charge: Dr. Lars Toleikis
Host Organization: Merck Healthcare KGAA (Merck), Germany
Scientist-in-Charge: Dr. Lars Toleikis
ESR13
"Validation and prospective application of allosteric binding site detection and ligand identification"
Host Organization: Janssen Pharmaceutica NV (Janssen), Belgium
Scientist-in-Charge: Dr. Herman van Vlijmen
Host Organization: Janssen Pharmaceutica NV (Janssen), Belgium
Scientist-in-Charge: Dr. Herman van Vlijmen
ESR14
"Allosteric modulation of GPCRs at the protein – membrane interface"
Host Organization: Univeristy of Urbino (UNIURB), Italy
Scientist-in-Charge: Prof. Giovanni Bottegoni
Host Organization: Univeristy of Urbino (UNIURB), Italy
Scientist-in-Charge: Prof. Giovanni Bottegoni
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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