Dr. Chris de Graaf
Host Organization Sosei Heptares Therapeutics Limited, United Kingdom Computational Chemistry ALLODD Role Main Supervisor for ESR10 |
Selected Publications Impact of GPCR Structures on Drug Discovery. Congreve M, de Graaf C, Swain NA, Tate CG. Cell. 2020 Apr 2;181(1):81-91. doi: 10.1016/j.cell.2020.03.003. Advances in therapeutic peptides targeting G protein-coupled receptors. Davenport AP, Scully CCG, de Graaf C, Brown AJH, Maguire JJ. Nat Rev Drug Discov. 2020 Jun;19(6):389-413. doi: 10.1038/s41573-020-0062-z. Epub 2020 Mar 19. Modulators of CXCR4 and CXCR7/ACKR3 Function. Adlere I, Caspar B, Arimont M, Dekkers S, Visser K, Stuijt J, de Graaf C, Stocks M, Kellam B, Briddon S, Wijtmans M, de Esch I, Hill S, Leurs R. Mol Pharmacol. 2019 Dec;96(6):737-752. doi: 10.1124/mol.119.117663. Epub 2019 Sep 23. Structural Analysis of Chemokine Receptor-Ligand Interactions. Arimont M, Sun SL, Leurs R, Smit M, de Esch IJP, de Graaf C. J Med Chem. 2017 Jun 22;60(12):4735-4779. doi: 10.1021/acs.jmedchem.6b01309. Epub 2017 Mar 10. The Landscape of Atypical and Eukaryotic Protein Kinases. Kanev GK, de Graaf C, de Esch IJP, Leurs R, Würdinger T, Westerman BA, Kooistra AJ. Trends Pharmacol Sci. 2019 Nov;40(11):818-832. doi: 10.1016/j.tips.2019.09.002. Epub 2019 Oct 31. 7TM Domain Structure of Adhesion GPCRs. de Graaf C, Nijmeijer S, Wolf S, Ernst OP. Extending the Structural View of Class B GPCRs. de Graaf C, Song G, Cao C, Zhao Q, Wang MW, Wu B, Stevens RC. Trends Biochem Sci. 2017 Dec;42(12):946-960. doi: 10.1016/j.tibs.2017.10.003. Epub 2017 Nov 11. Chemical Diversity in the G Protein-Coupled Receptor Superfamily. Vass M, Kooistra AJ, Yang D, Stevens RC, Wang MW, de Graaf C. Trends Pharmacol Sci. 2018 May;39(5):494-512. doi: 10.1016/j.tips.2018.02.004. Epub 2018 Mar 22. Molecular interaction fingerprint approaches for GPCR drug discovery. Vass M, Kooistra AJ, Ritschel T, Leurs R, de Esch IJ, de Graaf C. Curr Opin Pharmacol. 2016 Oct;30:59-68. doi: 10.1016/j.coph.2016.07.007. Epub 2016 Jul 29. Structure and Function of Peptide-Binding G Protein-Coupled Receptors. Wu F, Song G, de Graaf C, Stevens RC. J Mol Biol. 2017 Aug 18;429(17):2726-2745. doi: 10.1016/j.jmb.2017.06.022. Epub 2017 Jul 11. |
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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