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Dr. György Keserű

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Host Organization
Research Center for Natural Sciences, Hungary
Medicinal Chemistry Research Group
Keserű Lab

ALLODD Role
Main Supervisor for ESR7

Brief Bio
György M. Keserű obtained his Ph.D. at Budapest, Hungary and joined Sanofi heading a chemistry research lab. He moved to Gedeon Richter in 1999 as the Head of Computer-aided Drug Discovery. He earned D.Sc. from the Hungarian Academy of Science in 2003 and he was invited for a research professorship at the Budapest University of Technology and Economics. Since 2007 he was appointed as the Head of Discovery Chemistry at Gedeon Richter. He contributed to the discovery of the antipsychotic Vraylar® (cariprazine) that has been approved and marketed from 2016 in US and EU. He served as a director general of the Research Centre for Natural Sciences (RCNS) at the Hungarian Academy of Sciences. From 2015 he is heading the Medicinal Chemistry Research Group at RCNS. His research interests include medicinal chemistry, drug design. He has published over 230 papers and more than 10 books and book chapters. György was awarded by the prestigious Overton and Meyer Award of the European Federation of Medicinal Chemistry. He has been elected as Fellow of the Royal Society of Chemistry and as Corresponding member of the Hungarian Academy of Sciences.
Selected Publications
Exploring protein hotspots by optimized fragment pharmacophores
Dávid Bajusz, Warren S. Wade, Grzegorz Satała, Andrzej J. Bojarski, Janez Ilaš, Jessica Ebner, Florian Grebien, Henrietta Papp, Ferenc Jakab, Alice Douangamath, Daren Fearon, Frank von Delft, Marion Schuller, Ivan Ahel, Amanda Wakefield, Sándor Vajda, János Gerencsér, Péter Pallai, György M. Keserű
Nature Communications, 2021, 12, 3201.
 
Fragment evolution for GPCRs: the role of secondary binding sites in optimization
Florent Chevillard, Adam Kelemen, Jillian Baker, Vivien A Aranyodi, Frank Balzer, Peter Kolb, György Miklós Keserű
Chemical Communications, 2021, 57, 10516-10519.
 
Structural impact of GTP binding on downstream KRAS signaling
Dóra K. Menyhárd, Gyula Pálfy, Zoltán Orgován, István Vida, György M. Keserű, András Perczel
Chemical Science, 2020, 11, 9272-9289.
 
Controlling receptor function from the extracellular vestibule of G-protein coupled receptors
Attila Egyed, Katalin Domány-Kovács, Bence Koványi, Ferenc Horti, Dalma Kurkó, Dóra Judit Kiss, Gáspár Pándy-Szekeres, Istvan Greiner, György Miklós Keserű
Chemical Communications, 2020, 56, 14167-14170.
 
Expanding the medicinal chemistry synthetic toolbox
Jonas Boström, Dean G. Brown, Robert J. Young & György M. Keserű
Nature Reviews Drug Discovery, 2018, 17, 709-727.

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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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  • Home
    • ALLODD Overview
    • Governing Bodies
  • People
    • Beneficiaries
    • Partner Organisations
    • Supervisors
    • Early Stage Researchers
  • Research
    • Work Packages
    • Individual Research Projects
  • Training
    • Training Events >
      • 1st Workshop and PhD Induction Course
      • 1st Training School & Networking Meeting
      • Allostery in Drug Discovery Awareness Event and Symposium
      • 2nd Training School & Networking Meeting
      • IPR Training for Researchers & ESR Presentations on the Progress of their Research
      • 3rd Training School & Networking Meeting
      • European Conference in Allostery in Drug Discovery >
        • Abstract submission
        • Registration
      • Final Networking Meeting
    • Secondments
    • ALLODD Webinars
    • Courses & Lectures
    • Journal Club
  • Dissemination
    • Publications
    • Dissemination Events
    • Science Slams
    • Communication Material
    • Social Media
    • Newsletter
  • Events
    • ALLODD Events
    • Satellite Events
  • Newsroom
    • Press releases
  • Job Openings
  • Blog
  • Contact