Dr. György Keserű
György M. Keserű obtained his Ph.D. at Budapest, Hungary and joined Sanofi heading a chemistry research lab. He moved to Gedeon Richter in 1999 as the Head of Computer-aided Drug Discovery. He earned D.Sc. from the Hungarian Academy of Science in 2003 and he was invited for a research professorship at the Budapest University of Technology and Economics. Since 2007 he was appointed as the Head of Discovery Chemistry at Gedeon Richter. He contributed to the discovery of the antipsychotic Vraylar® (cariprazine) that has been approved and marketed from 2016 in US and EU. He served as a director general of the Research Centre for Natural Sciences (RCNS) at the Hungarian Academy of Sciences. From 2015 he is heading the Medicinal Chemistry Research Group at RCNS. His research interests include medicinal chemistry, drug design. He has published over 230 papers and more than 10 books and book chapters. György was awarded by the prestigious Overton and Meyer Award of the European Federation of Medicinal Chemistry. He has been elected as Fellow of the Royal Society of Chemistry and as Corresponding member of the Hungarian Academy of Sciences.
Exploring protein hotspots by optimized fragment pharmacophores
Dávid Bajusz, Warren S. Wade, Grzegorz Satała, Andrzej J. Bojarski, Janez Ilaš, Jessica Ebner, Florian Grebien, Henrietta Papp, Ferenc Jakab, Alice Douangamath, Daren Fearon, Frank von Delft, Marion Schuller, Ivan Ahel, Amanda Wakefield, Sándor Vajda, János Gerencsér, Péter Pallai, György M. Keserű
Nature Communications, 2021, 12, 3201.
Fragment evolution for GPCRs: the role of secondary binding sites in optimization
Florent Chevillard, Adam Kelemen, Jillian Baker, Vivien A Aranyodi, Frank Balzer, Peter Kolb, György Miklós Keserű
Chemical Communications, 2021, 57, 10516-10519.
Structural impact of GTP binding on downstream KRAS signaling
Dóra K. Menyhárd, Gyula Pálfy, Zoltán Orgován, István Vida, György M. Keserű, András Perczel
Chemical Science, 2020, 11, 9272-9289.
Controlling receptor function from the extracellular vestibule of G-protein coupled receptors
Attila Egyed, Katalin Domány-Kovács, Bence Koványi, Ferenc Horti, Dalma Kurkó, Dóra Judit Kiss, Gáspár Pándy-Szekeres, Istvan Greiner, György Miklós Keserű
Chemical Communications, 2020, 56, 14167-14170.
Expanding the medicinal chemistry synthetic toolbox
Jonas Boström, Dean G. Brown, Robert J. Young & György M. Keserű
Nature Reviews Drug Discovery, 2018, 17, 709-727.