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Dr. Marc Nazaré

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Host Organization
LEIBNIZ-RESEARCH INSTITUTE FOR MOLECULAR PHARMACOLOGY (FMP) in FORSCHUNGSVERBUND BERLIN EV (FVB), Germany
Medicinal Chemistry Research Group
Nazaré Lab

ALLODD Role
Main Supervisor for ESR8

Brief Bio
Marc Nazaré is a group leader in medicinal chemistry at the Leibniz Institut fuer Molekulare Pharmakologie FMP, Berlin, Germany. He studied chemistry at the University of Karlsruhe and obtained his PhD in organic chemistry in 1999 under the guidance of Prof. Herbert Waldmann working on a natural product total synthesis. He started his career in the pharmaceutical industry at Aventis (now Sanofi) in Frankfurt, as a medicinal chemist and project leader. Over the years he has been working on kinase-, GPCR-, protease- and ion channel projects covering both early and late-stage research. Marc Nazaré contributed to several clinical candidates of Factor Xa inhibitors and P2Y12 antagonists programs for the treatment of thrombosis. In 2013, he joined the Leibniz Institute for Molecular Pharmacology FMP to establish the medicinal chemistry group in the chemical biology department. His research interest is focused on the structure-based design and optimization of chemical probes and imaging tools for chemical biology.
Selected Publications
Mostinski Y, Heynen GJJE, López-Alberca MP, Paul J, Miksche S, Radetzki S, Schaller D, Shanina E, Seyffarth C, Kolomeets Y, Ziebart N, de Schryver J, Oestreich S, Neuenschwander M, Roske Y, Heinemann U, Rademacher C, Volkamer A, von Kries JP, Birchmeier W, Nazaré M
From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement
J Med Chem. 2020, 63(23):14780-14804
https://doi.org/10.1021/acs.jmedchem.0c01265

Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase
Nat Med. 2018, 24(7):954-960
https://doi.org/10.1038/s41591-018-0024-8

Brennecke B, Wang Q, Zhang Q, Hu HY, Nazaré M
An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria
Angew Chem Int Ed Engl. 2020, 59(22):8512-8516
https://doi.org/10.1002/anie.202002391

Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C
Allosteric Inhibition of a Mammalian Lectin
J Am Chem Soc. 2018, 140(44):14915-14925
https://doi.org/10.1021/jacs.8b08644

Schoene J, Gazzi T, Lindemann P, Christmann M, Volkamer A, Nazaré M
Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors
ChemMedChem. 2019, 14(16):1514-1527
https://doi.org/10.1002/cmdc.201900328

Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach
J Med Chem. 2017, 60(24):10013-10025
https://doi.org/10.1021/acs.jmedchem.7b00883

Sun H, Horatscheck A, Martos V, Bartetzko M, Uhrig U, Lentz D, Schmieder P, Nazaré M
Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances
Angew Chem Int Ed Engl. 2017, 56(23):6454-6458
https://doi.org/10.1002/anie.201700520

Nazaré M, Matter H, Will DW, Wagner M, Urmann M, Czech J, Schreuder H, Bauer A, Ritter K, Wehner V
Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes
Angew Chem Int Ed Engl. 2012, 51(4):905-911
https://doi.org/10.1002/anie.201107091
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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  • Home
    • ALLODD Overview
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    • Early Stage Researchers
  • Research
    • Work Packages
    • Individual Research Projects
  • Training
    • Training Events >
      • 1st Workshop and PhD Induction Course
      • 1st Training School & Networking Meeting
      • Allostery in Drug Discovery Awareness Event and Symposium
    • Secondments
    • ALLODD Webinars
    • Courses & Lectures
    • Journal Club
  • Dissemination
    • Publications
    • Events
    • Communication Material
    • Social Media
    • Newsletter
  • Events
    • ALLODD Events
    • ALLODD Webinars
    • Courses & Lectures
    • Satellite Events
  • Newsroom
  • Job Openings
  • Blog
  • Contact