Dr. Marc Nazaré
Host Organization LEIBNIZ-RESEARCH INSTITUTE FOR MOLECULAR PHARMACOLOGY (FMP) in FORSCHUNGSVERBUND BERLIN EV (FVB), Germany Medicinal Chemistry Research Group Nazaré Lab ALLODD Role Main Supervisor for ESR8 |
Brief Bio Marc Nazaré is a group leader in medicinal chemistry at the Leibniz Institut fuer Molekulare Pharmakologie FMP, Berlin, Germany. He studied chemistry at the University of Karlsruhe and obtained his PhD in organic chemistry in 1999 under the guidance of Prof. Herbert Waldmann working on a natural product total synthesis. He started his career in the pharmaceutical industry at Aventis (now Sanofi) in Frankfurt, as a medicinal chemist and project leader. Over the years he has been working on kinase-, GPCR-, protease- and ion channel projects covering both early and late-stage research. Marc Nazaré contributed to several clinical candidates of Factor Xa inhibitors and P2Y12 antagonists programs for the treatment of thrombosis. In 2013, he joined the Leibniz Institute for Molecular Pharmacology FMP to establish the medicinal chemistry group in the chemical biology department. His research interest is focused on the structure-based design and optimization of chemical probes and imaging tools for chemical biology. Selected Publications Mostinski Y, Heynen GJJE, López-Alberca MP, Paul J, Miksche S, Radetzki S, Schaller D, Shanina E, Seyffarth C, Kolomeets Y, Ziebart N, de Schryver J, Oestreich S, Neuenschwander M, Roske Y, Heinemann U, Rademacher C, Volkamer A, von Kries JP, Birchmeier W, Nazaré M From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement J Med Chem. 2020, 63(23):14780-14804 https://doi.org/10.1021/acs.jmedchem.0c01265 Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase Nat Med. 2018, 24(7):954-960 https://doi.org/10.1038/s41591-018-0024-8 Brennecke B, Wang Q, Zhang Q, Hu HY, Nazaré M An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria Angew Chem Int Ed Engl. 2020, 59(22):8512-8516 https://doi.org/10.1002/anie.202002391 Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C Allosteric Inhibition of a Mammalian Lectin J Am Chem Soc. 2018, 140(44):14915-14925 https://doi.org/10.1021/jacs.8b08644 Schoene J, Gazzi T, Lindemann P, Christmann M, Volkamer A, Nazaré M Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors ChemMedChem. 2019, 14(16):1514-1527 https://doi.org/10.1002/cmdc.201900328 Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach J Med Chem. 2017, 60(24):10013-10025 https://doi.org/10.1021/acs.jmedchem.7b00883 Sun H, Horatscheck A, Martos V, Bartetzko M, Uhrig U, Lentz D, Schmieder P, Nazaré M Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances Angew Chem Int Ed Engl. 2017, 56(23):6454-6458 https://doi.org/10.1002/anie.201700520 Nazaré M, Matter H, Will DW, Wagner M, Urmann M, Czech J, Schreuder H, Bauer A, Ritter K, Wehner V Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes Angew Chem Int Ed Engl. 2012, 51(4):905-911 https://doi.org/10.1002/anie.201107091 |
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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