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Dr. Patrick Scheerer

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Host Organization
Charité - Universitätsmedizin Berlin, Germany
Institute of Medical Physics and Biophysics
Scheerer Lab

ALLODD Role
Main Supervisor for ESR6

Selected Publications
Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kühnen P, Kobilka BK, Scheerer P
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide
Cell Res. 2021, 31(11):1176-1189
https://doi.org/10.1038/s41422-021-00569-8

Fudim R, Szczepek M, Vierock J, Vogt A, Schmidt A, Kleinau G, Fischer P, Bartl F, Scheerer P, Hegemann P
Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin
Sci Signal. 2019, 12(573):eaav4203
https://doi.org/10.1126/scisignal.aav4203

Schmidt A, Sauthof L, Szczepek M, Lopez MF, Escobar FV, Qureshi BM, Michael N, Buhrke D, Stevens T, Kwiatkowski D, von Stetten D, Mroginski MA, Krauß N, Lamparter T, Hildebrandt P, Scheerer P
Structural snapshot of a bacterial phytochrome in its functional intermediate state
Nat Commun. 2018, 9(1):4912
https://doi.org/10.1038/s41467-018-07392-7

Scheerer P, Unger E, Tian L
Protein structures guide the design of a much-needed tool for neuroscience
Nature. 2018, 561(7723):312-313
https://doi.org/10.1038/d41586-018-06670-0

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency
Nat Med. 2018, 24(5):551-555
https://doi.org/10.1038/s41591-018-0015-9

Kalms J, Schmidt A, Frielingsdorf S, Utesch T, Gotthard G, von Stetten D, van der Linden P, Royant A, Mroginski MA, Carpentier P, Lenz O, Scheerer P.
Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase

Proc Natl Acad Sci U S A. 2018; 115(10):E2229-E2237.
https://doi.org/10.1073/pnas.1712267115

Qureshi BM, Schmidt A, Behrmann E, Bürger J, Mielke T, Spahn CMT, Heck M, Scheerer P
Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6
Nat Commun. 2018, 9(1):90
https://doi.org/10.1038/s41467-017-02569-y

Scheerer P, Sommer ME
Structural mechanism of arrestin activation
Curr Opin Struct Biol. 2017, 45:160-169
https://doi.org/10.1016/j.sbi.2017.05.001

Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, Bürger J, Mielke T, Scheerer P, Spahn CM
Structural snapshots of actively translating human ribosomes
Cell. 2015, 161(4):845-857
https://doi.org/10.1016/j.cell.2015.03.052


Szczepek M, Beyrière F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P
Crystal structure of a common GPCR-binding interface for G protein and arrestin
Nat Commun. 2014, 5:4801
https://doi.org/10.1038/ncomms5801

Rose AS, Elgeti M, Zachariae U, Grubmüller H, Hofmann KP, Scheerer P, Hildebrand PW
Position of transmembrane helix 6 determines receptor G protein coupling specificity
J Am Chem Soc. 2014, 136(32):11244-11247
https://doi.org/10.1021/ja5055109

Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME
Crystal structure of pre-activated arrestin p44.
Nature. 2013, 497(7447):142-146
https://doi.org/10.1038/nature12133

Fritsch J, Scheerer P, Frielingsdorf S, Kroschinsky S, Friedrich B, Lenz O, Spahn CM
The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre

Nature. 2011, 479(7372):249-252
https://doi.org/10.1038/nature10505

Hofmann KP, Scheerer P, Hildebrand PW, Choe HW, Park JH, Heck M, Ernst OP
A G protein-coupled receptor at work: the rhodopsin model
Trends Biochem Sci. 2009, 34(11):540-552
https://doi.org/10.1016/j.tibs.2009.07.005


Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP
Crystal structure of metarhodopsin II
Nature. 2011, 471(7340):651-655
https://doi.org/10.1038/nature09789

Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP
Crystal structure of the ligand-free G-protein-coupled receptor opsin
Nature. 2008, 454(7201):183-187
https://doi.org/10.1038/nature07063

Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP
Crystal structure of opsin in its G-protein-interacting conformation
Nature. 2008, 455(7212):497-502
https://doi.org/10.1038/nature07330
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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  • Home
    • ALLODD Overview
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  • People
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    • Early Stage Researchers
  • Research
    • Work Packages
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  • Training
    • Training Events >
      • 1st Workshop and PhD Induction Course
      • 1st Training School & Networking Meeting
      • Allostery in Drug Discovery Awareness Event and Symposium
    • Secondments
    • ALLODD Webinars
    • Courses & Lectures
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    • Publications
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    • Communication Material
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  • Events
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  • Newsroom
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  • Blog
  • Contact