Dr. Patrick Scheerer
Host Organization Charité - Universitätsmedizin Berlin, Germany Institute of Medical Physics and Biophysics Scheerer Lab ALLODD Role Main Supervisor for ESR6 |
Selected Publications Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kühnen P, Kobilka BK, Scheerer P Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide Cell Res. 2021, 31(11):1176-1189 https://doi.org/10.1038/s41422-021-00569-8 Fudim R, Szczepek M, Vierock J, Vogt A, Schmidt A, Kleinau G, Fischer P, Bartl F, Scheerer P, Hegemann P Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin Sci Signal. 2019, 12(573):eaav4203 https://doi.org/10.1126/scisignal.aav4203 Schmidt A, Sauthof L, Szczepek M, Lopez MF, Escobar FV, Qureshi BM, Michael N, Buhrke D, Stevens T, Kwiatkowski D, von Stetten D, Mroginski MA, Krauß N, Lamparter T, Hildebrandt P, Scheerer P Structural snapshot of a bacterial phytochrome in its functional intermediate state Nat Commun. 2018, 9(1):4912 https://doi.org/10.1038/s41467-018-07392-7 Scheerer P, Unger E, Tian L Protein structures guide the design of a much-needed tool for neuroscience Nature. 2018, 561(7723):312-313 https://doi.org/10.1038/d41586-018-06670-0 Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency Nat Med. 2018, 24(5):551-555 https://doi.org/10.1038/s41591-018-0015-9 Kalms J, Schmidt A, Frielingsdorf S, Utesch T, Gotthard G, von Stetten D, van der Linden P, Royant A, Mroginski MA, Carpentier P, Lenz O, Scheerer P. Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase Proc Natl Acad Sci U S A. 2018; 115(10):E2229-E2237. https://doi.org/10.1073/pnas.1712267115 Qureshi BM, Schmidt A, Behrmann E, Bürger J, Mielke T, Spahn CMT, Heck M, Scheerer P Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6 Nat Commun. 2018, 9(1):90 https://doi.org/10.1038/s41467-017-02569-y Scheerer P, Sommer ME Structural mechanism of arrestin activation Curr Opin Struct Biol. 2017, 45:160-169 https://doi.org/10.1016/j.sbi.2017.05.001 Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, Bürger J, Mielke T, Scheerer P, Spahn CM Structural snapshots of actively translating human ribosomes Cell. 2015, 161(4):845-857 https://doi.org/10.1016/j.cell.2015.03.052 Szczepek M, Beyrière F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P Crystal structure of a common GPCR-binding interface for G protein and arrestin Nat Commun. 2014, 5:4801 https://doi.org/10.1038/ncomms5801 Rose AS, Elgeti M, Zachariae U, Grubmüller H, Hofmann KP, Scheerer P, Hildebrand PW Position of transmembrane helix 6 determines receptor G protein coupling specificity J Am Chem Soc. 2014, 136(32):11244-11247 https://doi.org/10.1021/ja5055109 Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME Crystal structure of pre-activated arrestin p44. Nature. 2013, 497(7447):142-146 https://doi.org/10.1038/nature12133 Fritsch J, Scheerer P, Frielingsdorf S, Kroschinsky S, Friedrich B, Lenz O, Spahn CM The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre Nature. 2011, 479(7372):249-252 https://doi.org/10.1038/nature10505 Hofmann KP, Scheerer P, Hildebrand PW, Choe HW, Park JH, Heck M, Ernst OP A G protein-coupled receptor at work: the rhodopsin model Trends Biochem Sci. 2009, 34(11):540-552 https://doi.org/10.1016/j.tibs.2009.07.005 Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP Crystal structure of metarhodopsin II Nature. 2011, 471(7340):651-655 https://doi.org/10.1038/nature09789 Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP Crystal structure of the ligand-free G-protein-coupled receptor opsin Nature. 2008, 454(7201):183-187 https://doi.org/10.1038/nature07063 Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP Crystal structure of opsin in its G-protein-interacting conformation Nature. 2008, 455(7212):497-502 https://doi.org/10.1038/nature07330 |
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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