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Dr. Vineet Pande

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Host Organization
Johnson & Johnson Innovative Medicine, Belgium
Computational Chemistry

ALLODD Role
Main Supervisor for ESR13
Brief Bio
Vineet Pande is currently leading a team of computational chemists & data scientists at Johnson & Johnson Innovative Medicine working on several drug discovery projects in multiple therapeutic areas. He has a track-record of applying computational solutions to small molecule drug discovery programs at all stages including target-evaluation through lead-optimization, working in global matrix teams & is a co-inventor of multiple novel molecules, currently in the clinic or moving successfully towards clinical trials. He has also established and co-led various external scientific collaborations and partnerships (e.g. with the Structural Genomics Consortium), integrating diverse disciplines of drug discovery and exploring emerging external science. Before joining Janssen in 2011, he gained extensive postdoctoral research experience in computational biophysics, computer-aided molecular design, and chemical biology at Karolinska Institute, AstraZeneca R&D and EMBL, respectively. Vineet holds a Masters in biological sciences and a Ph.D. degree in computational chemistry.
Selected Publications
Brehmer, D.; Beke, L; Wu, T. et al.
Discovery and pharmacological characterization of JNJ-64619178, a novel small molecule inhibitor of PRMT5 with potent antitumor activity
Mol. Cancer Ther. 2021, 20 (12), 2317.

Branch, J.R.; Bush, T.L.; Pande, V. et al.
Discovery of JNJ-63576253, a next-generation androgen receptor antagonist active against wild-type and clinically relevant ligand binding domain mutations in metastatic castration-resistant prostate cancer
Mol. Cancer. Ther. 2021, 20 (5), 763.

Pande, V.; Sun, W.; Beke, L. et al.
A chemical probe for the methyl transferase PRMT5 with a novel binding mode
ACS Med. Chem. Lett. 2020, 11 (11), 2227.

Embrechts, W.; Herschke, F.; Pauwels, F., et al.
2,4-Diaminoquinazolines as dual toll-like receptor (TLR) 7/8 modulators for the treatment of hepatitis B virus
J. Med. Chem. 2018, 61 (14), 6236.

Muller, S.; Ackloo, S.; Arrowsmith, C.H.; et al.
Donated chemical probes for open science
ELife. 2018,
7:e34311.

Pande, V.
Understanding the complexity of epigenetic target space
J. Med. Chem. 2016
, 59 (4), 1299.

Cabaye, A.; Nguyen, K.T.; Liu, L.; et al.
Structural diversity of epigenetics pocketome
Proteins 2015
, 83 (7), 1316.

Pande, V.; Pocalyko, D.J.; Dhanak, D.
Emerging epigenetic therapies- lysine methyltransferase/PRC complex inhibitors.
In book: Epigenetic Cancer Therapy (Academic Press) 2015. pp.427.

Pande, V., and Nilsson, L.
Insights into structure, dynamics, and hydration of locked nucleic acid (LNA) strand-based duplexes from molecular dynamics simulations
Nucleic Acids Res. 2008
, 36 (5), 1508.

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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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  • Home
    • ALLODD Overview
    • Governing Bodies
  • People
    • Beneficiaries
    • Partner Organisations
    • Supervisors
    • Early Stage Researchers
  • Research
    • Work Packages
    • Individual Research Projects
  • Training
    • Training Events >
      • 1st Workshop and PhD Induction Course
      • 1st Training School & Networking Meeting
      • Allostery in Drug Discovery Awareness Event and Symposium
      • 2nd Training School & Networking Meeting
      • IPR Training for Researchers & ESR Presentations on the Progress of their Research
      • 3rd Training School & Networking Meeting
      • European Conference in Allostery in Drug Discovery >
        • Abstract submission
        • Registration
      • Final Networking Meeting
    • Secondments
    • ALLODD Webinars
    • Courses & Lectures
    • Journal Club
  • Dissemination
    • Publications
    • Dissemination Events
    • Science Slams
    • Communication Material
    • Social Media
    • Newsletter
  • Events
    • ALLODD Events
    • Satellite Events
  • Newsroom
    • Press releases
  • Job Openings
  • Blog
  • Contact