Dr. Zoe Cournia
Host Organization Biomedical Research Foundation, Academy of Athens, Greece
Center for Clinical, Research, Experimental Surgery and Translational Research Cournia Lab ALLODD Role Project Coordinator Main Supervisor for ESR1 |
Brief Bio Zoe Cournia graduated from the Chemistry Department of the University of Athens and subsequently pursued doctoral studies in the University of Heidelberg, Germany, with Dr. Jeremy Smith. She obtained her Ph.D. degree in computational biophysical chemistry in 2006. Cournia then joined Dr. Bill Jorgensen's lab in the Department of Chemistry, Yale University, to perform post-doctoral studies in computer-aided drug design. At Yale, she focused on the design and discovery of novel anti-cancer agents and prediction of pharmacological properties using computational techniques. During 2007-2008 she served as a co-President of the Yale Pharmaceutical and Biotechnology Society and in 2009 she became a Lecturer in Yale College in 2009. For her research achievements, she has earned the AACR Fellowship for Cancer Research in Angiogenesis, the "Woman of Innovation 2009" Award from the Connecticut Technology Council USA, the Marie Curie Fellowship from the European Union (2010), the "Outstanding Junior Faculty Award" from the American Chemical Society (2014) and the first "Ada Lovelace Award" from the "Partnership for Advanced Computing in Europe" (2016). She is the Associate Editor of the Journal of Chemical information and Modeling, American Chemical Society, and a member of the Infrastructure Advisory Group (INFRAG) of the European High Performance Computing Joint Undertaking, European Commission. She is currently teaching at the Master’s program “Information Technologies in Technology and Medicine” at the Department of Informatics and Telecommunications, National and Kapodistrian University of Athens. She is the Founder of Ingredio, a mobile phone app that informs consumers on the potential hazards of chemical ingredients in food and cosmetics products using open, peer-reviewed data (http://www.ingred.io/android). Selected Publications Unravelling the effect of the E545K mutation on PI3Kα kinase Galdadas I, Gervasio, FL, Cournia Z Chem Sci, 2020, 11, 3511-3515 https://doi.org/10.1039/C9SC05903B Compounds for use in treating or preventing cancerous diseases Stellas D, Tamvakopoulos C, Klinakis A, Efstratiadis A, Cournia Z US Patent 2019 10,287,294B2 Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations. Leontiadou H, Galdadas I, Athanasiou C, Cournia Z* Sci Rep, 2018, 8(1):15544. http://dx.doi.org/10.1038/s41598-018-27044-6 Membrane Partitioning of Anionic, Ligand-Coated Nanoparticles Is Accompanied by Ligand Snorkeling, Local Disordering, and Cholesterol Depletion Gkeka, P, Angelikopoulos P, Sarkisov L, Cournia Z. PLoS Comput Biol. 2014, 10 (10):e1003917 http://dx.doi.org/10.1371/journal.pcbi.1003917 Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant. Gkeka P, Evangelidis T, Pavlaki M, Lazani V, Christoforidis S, Agianian B, Cournia Z. PLoS Comput Biol. 2014, 10 (10):e1003895. http://dx.doi.org/10.1371/journal.pcbi.1003895 ChemBioServer: a web-based pipeline for filtering, clustering and visualization of chemical compounds used in drug discovery. Athanasiadis E, Cournia Z, Spyrou G. Bioinformatics. 2012, 28(22), pp. 3002-3. http://dx.doi.org/10.1093/bioinformatics/bts551 Structural characterization and computer-aided optimization of a small-molecule inhibitor of the Arp2/3 complex, a key regulator of the actin cytoskeleton. Baggett AW, Cournia Z, Han MS, Patargias G, Glass AC, Liu SY, Nolen BJ. ChemMedChem. 2012, 7(7):1286-94. http://dx.doi.org/10.1002/cmdc.201200104 Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. Cournia Z, Leng L, Gandavadi S, Du X, Bucala R, Jorgensen WL. J Med Chem. 2009, 52(2):416-24. http://dx.doi.org/10.1021/jm801100v Differential effects of cholesterol, ergosterol and lanosterol on a dipalmitoyl phosphatidylcholine membrane: a molecular dynamics simulation study. Cournia Z, Ullmann GM, Smith JC. J Phys Chem B. 2007, 111(7):1786-801. http://dx.doi.org/10.1021/jp065172i A molecular mechanics force field for biologically important sterols. Cournia Z, Smith JC, Ullmann GM J Comput Chem. 2005, (13):1383-99. http://dx.doi.org/10.1002/jcc.20277 AFMM: A molecular mechanics force-field vibrational parametrization program. Vaiana AC, Cournia Z, Costescu IB, Smith JC Comput Phys Commun 2005, 167:34-42. http://dx.doi.org/10.1016/j.cpc.2004.12.005 Derivation of a Molecular Mechanics Force-Field for Cholesterol. Cournia Z, Vaiana AC, Smith JC, Ullmann GM Pure Appl Chem. 2004, 76:189-196. http://dx.doi.org/10.1351/pac200476010189 |
|
|
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
|
|
