Prof. Cristoph Rademacher
Prof. Christoph Rademacher earned his BSc in Molecular Biotechnology (2004) and MSc in Molecular Life Science (2006) at the University of Lübeck. In 2009, Prof. Rademacher received his doctorate from the same University, where he performed studies under the supervision of Prof. Dr. Thomas Peters in the Department of Chemistry working on virus/carbohydrate interactions using NMR spectroscopy. During these years, he also worked in Prof. Dr. David R. Bundle's and Prof. Dr. Todd Lowary's laboratories at the Alberta Ingenuity Center for Carbohydrate Science in Edmonton (Canada) and in Dr. Daron Freedberg's group at CBER/FDA in Bethesda (USA). He then underwent postdoctoral training with Prof. Dr. James C. Paulson at The Scripps Research Institute (USA) in the Department of Chemical Physiology, where he entered the field of glycoimmunology. In December 2011, Dr. Rademacher is appointed at the Max Planck Institute of Colloids and Interfaces in the Department of Biomolecular Systems, where he became Emmy-Noether Research Group Leader in June 2012. In 2017, Prof. Rademacher holds an ERC Starting Grant and in 2020 he was appointed full professor at the University of Vienna and the Max F. Perutz Laboratories. His research is focused on the development and application of novel molecular probes to understand the role of carbohydrates in immune cell regulation with a strong emphasis on molecular drug targeting.
Druggable Allosteric Sites in β-Propeller Lectins
Shanina E, Kuhaudomlarp S, Lal K, Seeberger PH, Imberty A, Rademacher C
Angew Chem Int Ed Engl. 2021, [published online ahead of print, 2021 Oct 29]
Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins
Kuhaudomlarp S, Siebs E, Shanina E, Topin J, Joachim I, da Silva Figueiredo Celestino Gomes P, Varrot A, Rognan D, Rademacher C, Imberty A, Titz A
Angew Chem Int Ed Engl. 2021, 60(15):8104-8114
Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin
Rentzsch M, Wawrzinek R, Zelle-Rieser C, Strandt H, Bellmann L, Fuchsberger F. F, Schulze J, Busmann J, Rademacher J, Sigl S, Del Frari B, Stoitzner P, Rademacher C
Front Immunol. 2021,12:732298
A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting
Wamhoff E. C, Schulze J, Bellmann L, Rentzsch M, Bachem G, Fuchsberger F. F, Rademacher J, Hermann M, Del Frari B, van Dalen R, Hartmann D, van Sorge N. M, Seitz O, Stoitzner P, Rademacher C
ACS Cent Sci. 2019, 5(5):808-820
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing
Schulze J, Rentzsch M, Kim D, Bellmann L, Stoitzner P, Rademacher C
Biochemistry. 2019, 58(21):2576-2580
A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN
Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger FF, Zhang H, Modenutti C, Schnirch L, Marti MA, Schwardt O, Bräutigam M, Guberman M, Hauck D, Seeberger PH, Seitz O, Titz A, Ernst B, Rademacher C.
J Am Chem Soc. 2021, 143(45):18977-18988
Intradomain Allosteric Network Modulates Calcium Affinity of the C-Type Lectin Receptor Langerin
Hanske J, Aleksić S, Ballaschk M, Jurk M, Shanina E, Beerbaum M, Schmieder P, Keller BG, Rademacher C.
J Am Chem Soc. 2016, 138(37):12176-12186
Identification of Multiple Druggable Secondary Sites by Fragment Screening against DC-SIGN
Aretz J, Baukmann H, Shanina E, Hanske J, Wawrzinek R, Zapol'skii VA, Seeberger PH, Kaufmann DE, Rademacher C.
Angew Chem Int Ed Engl. 2017, 56(25):7292-7296
Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa
Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A
J Am Chem Soc. 2018, 140(7):2537-2545
Allosteric Inhibition of a Mammalian Lectin
Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C
J Am Chem Soc. 2018, 140(44):14915-14925