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Prof. Cristoph Rademacher

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Host Organization
Department of Pharmaceutical Sciences
University of Vienna, Austria
Molecular Drug Targeting Group (MDT)

ALLODD Role
Main Supervisor for ESR2

Brief Bio
Prof. Christoph Rademacher earned his BSc in Molecular Biotechnology (2004) and MSc in Molecular Life Science (2006) at the University of Lübeck. In 2009, Prof. Rademacher received his doctorate from the same University, where he performed studies under the supervision of Prof. Dr. Thomas Peters in the Department of Chemistry working on virus/carbohydrate interactions using NMR spectroscopy. During these years, he also worked in Prof. Dr. David R. Bundle's and Prof. Dr. Todd Lowary's laboratories at the Alberta Ingenuity Center for Carbohydrate Science in Edmonton (Canada) and in Dr. Daron Freedberg's group at CBER/FDA in Bethesda (USA). He then underwent postdoctoral training with Prof. Dr. James C. Paulson at The Scripps Research Institute (USA) in the Department of Chemical Physiology, where he entered the field of glycoimmunology. In December 2011, Dr. Rademacher is appointed at the Max Planck Institute of Colloids and Interfaces in the Department of Biomolecular Systems, where he became Emmy-Noether Research Group Leader in June 2012. In 2017, Prof. Rademacher holds an ERC Starting Grant and in 2020 he was appointed full professor at the University of Vienna and the Max F. Perutz Laboratories. His research is focused on the development and application of novel molecular probes to understand the role of carbohydrates in immune cell regulation with a strong emphasis on molecular drug targeting.

Selected Publications
Druggable Allosteric Sites in β-Propeller Lectins
Shanina E, Kuhaudomlarp S, Lal K, Seeberger PH, Imberty A, Rademacher C
Angew Chem Int Ed Engl. 2021, [published online ahead of print, 2021 Oct 29]
https://doi.org/10.1002/anie.202109339

Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins
Kuhaudomlarp S, Siebs E, Shanina E, Topin J, Joachim I, da Silva Figueiredo Celestino Gomes P, Varrot A, Rognan D, Rademacher C, Imberty A, Titz A
Angew Chem Int Ed Engl. 2021, 60(15):8104-8114
https://doi.org/10.1002/anie.202013217

Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin
Rentzsch M, Wawrzinek R, Zelle-Rieser C, Strandt H, Bellmann L, Fuchsberger F. F, Schulze J, Busmann J, Rademacher J, Sigl S, Del Frari B, Stoitzner P, Rademacher C
Front Immunol. 2021,12:732298
https://doi.org/10.3389/fimmu.2021.732298

A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting
Wamhoff E. C, Schulze J, Bellmann L, Rentzsch M, Bachem G, Fuchsberger F. F, Rademacher J, Hermann M, Del Frari B, van Dalen R, Hartmann D, van Sorge N. M, Seitz O, Stoitzner P, Rademacher C
ACS Cent Sci. 2019, 5(5):808-820
https://doi.org/10.1021/acscentsci.9b00093

A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing
Schulze J, Rentzsch M, Kim D, Bellmann L, Stoitzner P, Rademacher C
Biochemistry. 2019, 58(21):2576-2580
https://doi.org/10.1021/acs.biochem.9b00402 

A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN
Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger FF, Zhang H, Modenutti C, Schnirch L, Marti MA, Schwardt O, Bräutigam M, Guberman M, Hauck D, Seeberger PH, Seitz O, Titz A, Ernst B, Rademacher C.
J Am Chem Soc. 2021, 143(45):18977-18988
https://doi.org/10.1021/jacs.1c07235

Intradomain Allosteric Network Modulates Calcium Affinity of the C-Type Lectin Receptor Langerin
Hanske J, Aleksić S, Ballaschk M, Jurk M, Shanina E, Beerbaum M, Schmieder P, Keller BG, Rademacher C.
J Am Chem Soc. 2016, 138(37):12176-12186
https://doi.org/10.1021/jacs.6b05458

Identification of Multiple Druggable Secondary Sites by Fragment Screening against DC-SIGN
Aretz J, Baukmann H, Shanina E, Hanske J, Wawrzinek R, Zapol'skii VA, Seeberger PH, Kaufmann DE, Rademacher C.
Angew Chem Int Ed Engl. 2017, 56(25):7292-7296
https://doi.org/10.1002/anie.201701943

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa
Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A
J Am Chem Soc. 2018, 140(7):2537-2545
https://doi.org/10.1021/jacs.7b11133

Allosteric Inhibition of a Mammalian Lectin
Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C
J Am Chem Soc. 2018, 140(44):14915-14925
https://doi.org/10.1021/jacs.8b08644
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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  • Home
    • ALLODD Overview
    • Governing Bodies
  • People
    • Beneficiaries
    • Partner Organisations
    • Supervisors
    • Early Stage Researchers
  • Research
    • Work Packages
    • Individual Research Projects
  • Training
    • Training Events >
      • 1st Workshop and PhD Induction Course
      • 1st Training School & Networking Meeting
      • Allostery in Drug Discovery Awareness Event and Symposium
    • Secondments
    • ALLODD Webinars
    • Courses & Lectures
    • Journal Club
  • Dissemination
    • Publications
    • Events
    • Communication Material
    • Social Media
    • Newsletter
  • Events
    • ALLODD Events
    • ALLODD Webinars
    • Courses & Lectures
    • Satellite Events
  • Newsroom
  • Job Openings
  • Blog
  • Contact