Prof. Cristoph Rademacher
Host Organization Department of Pharmaceutical Sciences University of Vienna, Austria Molecular Drug Targeting Group (MDT) ALLODD Role Main Supervisor for ESR2 |
Brief Bio Prof. Christoph Rademacher earned his BSc in Molecular Biotechnology (2004) and MSc in Molecular Life Science (2006) at the University of Lübeck. In 2009, Prof. Rademacher received his doctorate from the same University, where he performed studies under the supervision of Prof. Dr. Thomas Peters in the Department of Chemistry working on virus/carbohydrate interactions using NMR spectroscopy. During these years, he also worked in Prof. Dr. David R. Bundle's and Prof. Dr. Todd Lowary's laboratories at the Alberta Ingenuity Center for Carbohydrate Science in Edmonton (Canada) and in Dr. Daron Freedberg's group at CBER/FDA in Bethesda (USA). He then underwent postdoctoral training with Prof. Dr. James C. Paulson at The Scripps Research Institute (USA) in the Department of Chemical Physiology, where he entered the field of glycoimmunology. In December 2011, Dr. Rademacher is appointed at the Max Planck Institute of Colloids and Interfaces in the Department of Biomolecular Systems, where he became Emmy-Noether Research Group Leader in June 2012. In 2017, Prof. Rademacher holds an ERC Starting Grant and in 2020 he was appointed full professor at the University of Vienna and the Max F. Perutz Laboratories. His research is focused on the development and application of novel molecular probes to understand the role of carbohydrates in immune cell regulation with a strong emphasis on molecular drug targeting. Selected Publications Druggable Allosteric Sites in β-Propeller Lectins Shanina E, Kuhaudomlarp S, Lal K, Seeberger PH, Imberty A, Rademacher C Angew Chem Int Ed Engl. 2021, [published online ahead of print, 2021 Oct 29] https://doi.org/10.1002/anie.202109339 Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins Kuhaudomlarp S, Siebs E, Shanina E, Topin J, Joachim I, da Silva Figueiredo Celestino Gomes P, Varrot A, Rognan D, Rademacher C, Imberty A, Titz A Angew Chem Int Ed Engl. 2021, 60(15):8104-8114 https://doi.org/10.1002/anie.202013217 Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin Rentzsch M, Wawrzinek R, Zelle-Rieser C, Strandt H, Bellmann L, Fuchsberger F. F, Schulze J, Busmann J, Rademacher J, Sigl S, Del Frari B, Stoitzner P, Rademacher C Front Immunol. 2021,12:732298 https://doi.org/10.3389/fimmu.2021.732298 A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting Wamhoff E. C, Schulze J, Bellmann L, Rentzsch M, Bachem G, Fuchsberger F. F, Rademacher J, Hermann M, Del Frari B, van Dalen R, Hartmann D, van Sorge N. M, Seitz O, Stoitzner P, Rademacher C ACS Cent Sci. 2019, 5(5):808-820 https://doi.org/10.1021/acscentsci.9b00093 A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Schulze J, Rentzsch M, Kim D, Bellmann L, Stoitzner P, Rademacher C Biochemistry. 2019, 58(21):2576-2580 https://doi.org/10.1021/acs.biochem.9b00402 A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger FF, Zhang H, Modenutti C, Schnirch L, Marti MA, Schwardt O, Bräutigam M, Guberman M, Hauck D, Seeberger PH, Seitz O, Titz A, Ernst B, Rademacher C. J Am Chem Soc. 2021, 143(45):18977-18988 https://doi.org/10.1021/jacs.1c07235 Intradomain Allosteric Network Modulates Calcium Affinity of the C-Type Lectin Receptor Langerin Hanske J, Aleksić S, Ballaschk M, Jurk M, Shanina E, Beerbaum M, Schmieder P, Keller BG, Rademacher C. J Am Chem Soc. 2016, 138(37):12176-12186 https://doi.org/10.1021/jacs.6b05458 Identification of Multiple Druggable Secondary Sites by Fragment Screening against DC-SIGN Aretz J, Baukmann H, Shanina E, Hanske J, Wawrzinek R, Zapol'skii VA, Seeberger PH, Kaufmann DE, Rademacher C. Angew Chem Int Ed Engl. 2017, 56(25):7292-7296 https://doi.org/10.1002/anie.201701943 Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A J Am Chem Soc. 2018, 140(7):2537-2545 https://doi.org/10.1021/jacs.7b11133 Allosteric Inhibition of a Mammalian Lectin Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C J Am Chem Soc. 2018, 140(44):14915-14925 https://doi.org/10.1021/jacs.8b08644 |
|
|
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
|
|
