Prof. Jordi Juárez-Jiménez
Host Organization University of Barcelona, Spain Faculty of Pharmacy and Food Sciences CMD Lab ALLODD Role Main Supervisor for ESR3 |
Jordi Juárez is an Assistant Professor at the Faculty of Pharmacy and Food Sciences of the University of Barcelona. He graduated in Pharmacy in 2008 and was a trainee Medicinal Chemist at GlaxoSmithKline before joining the group of Prof. F. J. Luque to pursue his PhD in computational chemistry (awarded in 2014). He spent a short postdoctoral internship with Prof. A. Roitberg at the University of Florida (2015), before joining the laboratory of Dr. J. Michel at the University of Edinburgh first as a Marie Sklodowska-Curie postdoctoral fellow (2015-2017) and subsequently as named researcher in ERC-PoC (2017-2019) and EPSRC (2019-2020) funded projects. Since 2021 he is the Group Leader of the of the Computational Molecular Design lab, devoted to advancing the field of biomolecular simulations by creating a research environment that encourages learning, critical thinking, and scientific and personal growth. He has co-authored more than 20 scientific publications, including research papers, reviews, and book chapters, as well as 1 patent. His research has a multidisciplinary focus, aiming at pushing the boundaries of biomolecular simulations and its integration with experimental techniques. He is particularly interested in unraveling the molecular determinants underpinning novel therapeutic strategies, including selective stabilization of protein-protein interfaces and allosteric modulation of targets traditionally deemed as “unligandable”. Combining physical chemistry, biomolecular modelling and experimental collaboration the CMD lab strives to expedite the discovery of new chemical matter that can be further develop into drugs.
Miñarro-Lleonar, Marina; Bertran-Mostazo, Andrea; Duro Jorge; Barril, Xavier; Juárez-Jiménez, Jordi Lenalidomide stabilizes protein-protein complexes by turning labile intermolecular H-bonds into robust interactions (Journal Article) In: Journal of Medicinal Chemistry, 2023, 66, 9, 6037-6046 Scott, Jamie I.; Mendive-Tapia, Lorena; Gordon, Doireann; Barth, Nicole D.; Thompson, Emily J.; Cheng, Zhiming; Taggart, David; Kitamura, Takanori; Bravo-Blas, Alberto; Roberts, Edward W.; Juarez-Jimenez, Jordi; Michel, Julien; Piet, Berber; Vries, I. Jolanda; Verdoes, Martijn; Dawson, John; Carragher, Neil O.; Connor, Richard A. O’; Akram, Ahsan R.; Frame, Margaret; Serrels, Alan; Vendrell, Marc A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies (Journal Article) In: Nature Communications, vol. 13, no. 1, 2022, ISSN: 2041-1723. Juárez-Jiménez, Jordi; Tew, Philip; O′Connor, Michael; Llabrés, Salomé; Sage, Rebecca; Glowacki, David; Michel, Julien Combining Virtual Reality Visualization with Ensemble Molecular Dynamics to Study Complex Protein Conformational Changes (Journal Article) In: Journal of Chemical Information and Modeling, vol. 60, no. 12, pp. 6344–6354, 2020, ISSN: 1549-960X. Kuzmanic, Antonija; Bowman, Gregory R.; Juarez-Jimenez, Jordi; Michel, Julien; Gervasio, Francesco L. Investigating Cryptic Binding Sites by Molecular Dynamics Simulations (Journal Article) In: Accounts of Chemical Research, vol. 53, no. 3, pp. 654–661, 2020, ISSN: 1520-4898. Juárez-Jiménez, Jordi; Gupta, Arun A.; Karunanithy, Gogulan; Mey, Antonia S. J. S.; Georgiou, Charis; Ioannidis, Harris; Simone, Alessio De; Barlow, Paul N.; Hulme, Alison N.; Walkinshaw, Malcolm D.; Baldwin, Andrew J.; Michel, Julien Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A (Journal Article) In: Chemical Science, vol. 11, no. 10, pp. 2670–2680, 2020, ISSN: 2041-6539 |
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This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956314.
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