Blog Archives

AlphaFold training course

15/3/2024

Course contents

An introductory guide to AlphaFold’s strengths and limitations
- What are proteins and how do we know their structures?
- What is the protein folding problem?
- What is AlphaFold?
- Strengths and limitations of AlphaFold2
- Test your knowledge
Validation and impact
- How have AlphaFold2’s predictions of protein structure been validated?
- How accurate are AlphaFold2 structure predictions?
- How is AlphaFold2 used by scientists?
Inputs and outputs
- AlphaFold2: A high-level overview
- Evaluating AlphaFold2’s predicted structures using confidence scores
- pLDDT: Understanding local confidence
- PAE: A measure of global confidence in AlphaFold2 predictions
- Confidence scores in AlphaFold-Multimer
- AlphaFold2 inputs and outputs – Recap
- Other tools to check quality of the predicted structures
Accessing and predicting protein structures with AlphaFold2
- Choosing how to access AlphaFold2
- Accessing predicted protein structures in the AlphaFold Database
- What’s the best way to access the database?
- Predicting protein structures with ColabFold and AlphaFold2 Colab
- Predicting protein structures using the AlphaFold2 open-source code
- Other ways to access predicted protein structures
- How to cite AlphaFold
Advanced modelling and applications of predicted protein structures
- Customising AlphaFold2 structure predictions
- Outputs from ColabFold
- Using AlphaFold2 predicted structures to tackle deeper questions
- Enhancements to AlphaFold2 from the wider scientific community
Future directions and summary
- Current and future developments of AlphaFold2
- Key takeaways about AlphaFold2

Date: Anytime
Duration: 3 hours
Venue: online
This training module on AlphaFold2 has been developed in collaboration with Google DeepMind

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17th EFMC-YSN MedChemBioOnline

14/3/2024

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PROGRAMME:

16:30 | Welcome and Introduction
16:40 | Rethinking Failure: Lessons Learned from the Lab's Untold Stories
Prof. Daniel Rauh (TU Dortmund, Germany)
17:00 | Topical JAK Inhibitors for Atopic Dermatitis: From “soft” to “super-soft”
Dr Gebhard Thoma (Novartis, Switzerland)
17:20 | Sponsor Presentation
Dr Luc Van Hijfte (Symeres, The Netherlands)
17:30 | Combining Data-driven and Chemoinformatical False Positive Mitigation Strategies in High-throughput Screening
Dr Michael Margreiter (Evotec, Germany)
17:50 | Round Table Discussion
- Dr Stéphanie Gueret (AstraZeneca, Sweden)
- Dr Michael Margreiter (Evotec, Germany)
- Prof. Daniel Rauh (TU Dortmund, Germany)
- Dr Gebhard Thoma (Novartis, Switzerland)
- Dr Luc Van Hijfte (Symeres, The Netherlands)
18:30 | End of the Webinar

Date: March 26, 2024, 16:30 - 18:30 (CET)
Venue: online
The event is free and open to everyone thanks to the support of Symeres.

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Registration

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The 13th ALLODD webinar was hosted by the Bayer AG, Germany

Title: "Understanding allostery with integrated structural biology approaches."
Speaker: Dr. John O’Donnell

Date: March 06, 2024

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IPR Training for Researchers & ESR Presentations on the Progress of their Research

11/3/2024

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The fifth ALLODD event "IPR Training for Researchers & ESR Presentations on the Progress of their Research" was successfully held on February 27-March 01, 2024!

Host Organization: Janssen Pharmaceutical NV, Belgium

Scientists-in-charge:
Dr. Vineet Pande
Dr. Herman van Vlijmen

Find out more about the program of the event here.

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AlphaFold training course​

17th EFMC-YSN MedChemBioOnline​

13th ALLODD webinar

IPR Training for Researchers & ESR Presentations on the Progress of their Research

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AlphaFold training course

17th EFMC-YSN MedChemBioOnline